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Cytomorphology Analysis 2

LAB OSE



Papillary carcinoma of thyroid
Thyroid Cytology
Powdery chromatin
Pseudo inclusion
Nuclear groove
Nucleolus
Nuclear crowding
Nuclear molding 


Sputum - Alveolar macrophage
Respiratory Cytology
Nuclear enlargement
High N:C
Multinucleation
Nucleolus
Vacuolated cytoplasm


BAL - CMV
Respiratory Cytology
Nuclear enlargement
High N:C
Large eosinophilic intranuclear viral inclusions
Prominent halo


Metastatic papillary carcinoma of the thyroid
Thyroid Cytology
Psammoma body
Powdery chromatin
Nuclear crowding
Nucleolus
Nuclear grooves
Intranuclear pseudo inclusion


Bronchial washing - bronchial cells
Respiratory Cytology
Ciliated columnar cells
Central located nucleus
Cohesive sheets


Small cell undifferentiated carcinoma
Respiratory Cytology
Nuclear molding
Small cells
Small to indistinct nucleoli
Even, powdery chromatin
No cytoplasm


Medullary carcinoma of the thyroid
Thyroid cytology
Coarse chromatin
Hyperchromatic
Round or elongated nucleus
Inconspicuous nucleolus


Bronchial washing - cryptococcus
Respiratory Cytology
Narrow-based budding
Yeast cells
Prominent halo
Mucin capsule
Variably sized



Invasive lobular carcinoma
Breast Cytology
Nuclear enlargement
High N:C
Signet ring appearance (vacuole)
Nuclear molding
Isolated cells
Hyperchromatic
Eccentric/kidney bean nucleus


Benign follicular nodules
Thyroid Cytology
Macro follicles
Fragmented (flat sheets)
Intact spheres
Coarse chromatin 
Hyperchromatic
Colloid
Macrophages
Cohesive cells


Invasive ductal carcinoma
Breast Cytology
Comet cells
Eccentric nucleus often protruding from cytoplasm
Hyperchromatic
Coarse chromatin
Nucleolus
Clean background 
Isolated cells
Poorly cohesive clusters of cells


Fibroadenoma (benign)
Breast Cytology
Hypercellular
Large sheets
3D clusters
Antler-like configuration
Bipolar cells
Fibrillar stromal fragments


Umbrella cells
Urine Cytology
Multinucleation
Nucleolus
Irregular cell membrane
Vacuole
Hyperchromatic


Benign breast cyst
Breast Cytology
Ductal epithelial cells
(Apocrine cells)
Flat sheets
Isolated cells (rare)
Central located nuclei
Prominent nucleoli
Moderate nuclear atypia
Vacuolated cytoplasm (macrophages/foam cells)


Transitional Cell Carcinoma Grade III
Urine Cytology
Bizarre cells
Irregular nuclear borders
Chromatin clearing
Mitoses
Dirty background (blood, debris, inflammatory cells)


Polyoma virus
Urine Cytology
Decoy cells
(Plasmacytoid cells)
Eccentric nuclei
Basophilic intranuclear viral inclusions 
Mimic malignancy



Hashimoto thyroiditis (benign)
Thyroid Cytology
Mixed populations of lymphocytes
Tangible-body macrophages
Dendritic-lymphocytic aggregates
Follicular cells with nuclear pallor and grooves
Hurtle cells
Scant colloid


Carcinoma in situ
Urine Cytology
Nuclear enlargement 
High N:C
Hyperchromatic
Coarse chromatin
Pleomorphic nuclei
Mitotic activity
Clean background


Metastatic adenocarcinoma of lungs (pleural)
Effusion Cytology
Pale cytoplasm
Hyperchromatic
Multiple nucleoli
Nuclear enlargement
High N:C
Acinar, papillary and sheet formations


Reactive urothelial cells
Urine Cytology
Nuclear enlargement
High N:C
Prominent nucleolus
Coarse chromatin 
Hyperchromatic
Abundant cytoplasm
Multinucleation
Honeycomb
Dirty background (lysed blood, inflammation or crystals)


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